DHEA-S – From Alternative Source




Marketing Short note of “Dhea-s”.

Product Details & pathway to induce the effects.

Back ground of clinical Research on elevation of basal level of DHEA. – Although science has known about DHEA for almost 50 years, there were relatively few clinical studies until about ten years ago. The recent volume of research, however, has arguably made up for the previous short-fall. The research thus far is exciting in many ways.

Product – “Voage dhea” suggests a promising way to provide a “natural,” legal way to raise Testosterone & Estrogens levels through Cholesterol – DHEA pathway.

While the chain begins from Cholesterol, Pregnenolone is the first hormone of the

DHEA, short for dehydroepiandrosterone, is the most abundant hormone in the human body. It is an essential component in a host of physiological functions. It plays a major role in the function of the immune system. It is an important factor in determining general levels of well- being and mood. Most important for our purposes, however, is that it is a building block for androgenic sex hormones. Although science has known about DHEA for almost 50 years, there were relatively few clinical studies until about ten years ago. The recent volume of research, however, has arguably made up for the previous short-fall. The research thus far is exciting in many ways.

Perhaps the most scientifically interesting discovery is that DHEA may be the single most important chemical in the body for predicting disease states. As it happens, DHEA is measurably deficient in nearly every major category of disease, including obesity, diabetes, high blood pressure, cancer, immune deficiencies, coronary artery disease and autoimmune disorders.
Our study is pertaining to

Natural, non-exogenous, enhancement of DHEA levels – The same may be feasible and more desirable and/or effective. The same study is conducted with the alternative mineral source.

DHEA is manufactured from Cholesterol in the body. Interestingly, while DHEA levels decline with age, Cholesterol levels tend to rise. This has lead to speculation that there is some enzymatic conversion process that degrades with age. As Pregnenolone levels also fall with age, it is likely that this degradation is related to the interaction of ACTH on the conversion of Cholesterol. Normally, Pregnenolone proceeds along metabolic pathways to become either Progesterone or DHEA.

Progesterone proceeds to Cortisol and other glucocorticoids, Aldosterone and the mineral-corticoids via 21-Hydroxylase. This Hydroxylase enzyme is critical to the production of a wide range of corticosteroids. Individuals who are deficient in this enzyme experience significant, often devastating behavioral and physical sexual development problems.

Continuing along the Progesterone pathway, we find it becomes a building block for Estriol (a form of Estrogen). As noted, it also become Cortisol through the intermediate of 17-Alpha Hydroxy Progesterone. As you probably know, Cortisol is the major adrenal stress hormone and plays an active role in the catabolic effect of exercise. One of the pathways for the affect of Anabolic Steroids is theorized to be the binding of Cortisol receptors by the exogenous steroids. This effectively foils the catabolic effect but at too high a price. As Cortisol plays an essential role in the replacement and regeneration of damaged joint and tendon tissue, blocking it encourages serious injury in the form of torn muscle attachments in steroid users.

Another hormone produced via the Progesterone pathway is Aldosterone which is the major adrenal hormone responsible for mineral balance. Along with other mineral corticoids, Aldosterone is critical to maintaining proper hydration, bone density and contractile strength in muscle. Some bodybuilders have experimented with manipulating these corticoids in an effort to reduce water retention before contest. Apart from the extreme difficulty with producing the intended effect, tampering with this class of substrates is potentially fatal.

As you can see in the chart, Progesterone also goes on to become Estrone and 17-Beta Estradiol. The dotted line indicates that there are a number of other stages along the way. There is also another pathway, not illustrated, which leads to its conversion to Testosterone. This is not, however, a major source of circulating levels. The volume and affect of the estrogens derived from Progesterone when compared to androgens strongly favors feminizing effects.

Returning to the top of the chain, the other product of Pregnenolone is DHEA. This is the ordinary pathway for the manufacture of DHEA in the body. Illustrated but not detailed in the chart are the actions of DHEA as a major regulator in the feedback loop for all other hormones in the body, including Thyroid and Pituitary hormones. It is this function that leads to many of the quality of life and longevity benefits that appear to accrue from DHEA. We will discuss some of them a little later. Also apparent from the chart is the path that leads from DHEA to Testosterone (and 17-Beta Estradiol, yet another form of Estrogen). The immediate precursor to Testosterone is 4-Androstene-3, 17-dione, commonly known as Androstenedione or Androstene. The regulating enzyme for the conversion of Androstene to Testosterone is a by-product of Luteinizing Hormone known as 17-Beta-hydroxysteroid dihydrogenase. As you can see from the chart, production of this enzyme is govern by a negative feedback loop involving secretions from the pituitary and hypothalamus glands.
It is interesting to note that both the Progesterone and DHEA pathways can lead to the production of Testosterone and the various estrogens.

Androstene and/or DHEA and Androstene together will be effective. The rash of products, ads articles and hype are, nevertheless, quite premature for the predicate that they increase active Testosterone levels or anabolic effect through that pathway. By the way, it is beyond the scope of this article but we are quite aware of the assertion that Tribulus Terrestris, a source of Furostanol Saponins, (an herbal complex) raises 17-Beta hydroxysteroid hydrogenase levels.

The latest research on DHEA in obesity reveals that weight loss leads to Insulin reduction and 125 percent increase in DHEA in men. This seems to suggest that the body likes to lose weight through the DHEA pathway, but that may be wishful thinking.

Cautions for Synthetic DHEA. – There are no reported significant complications from DHEA supplementation However with synthetic DHEA some side effects have been observed. Mild acne and, rarely, some facial hair growth in older women has been reported. This may not be directly attributable to DHEA (older women frequently develop some facial hair).

Women with a family history of breast cancer or even benign cysts should not experiment with DHEA without the assistance of a knowledgeable physician. Men with any prostate problem, including BPH, should also use DHEA only under medical supervision. Apart from these caveats, the most important contraindication is patients with diagnosed cancer (although it may be helpful with some cancers). Women with endometriosis or fibroids are also ill advised to use DHEA.

Ban of Synthetic DHEA in USA. – Two organizations, the United States Olympic Committee(USOC) and the American College of Sports Medicine(ACSM) have defined the role of DHEA supplement use to the “Anabolic Banned Substance” category. USOC specifically lists DHEA as an androgenic anabolic steroid-class banned substance. In the “USOC Guide to Prohibited Substances and Methods” they state, “The presence of testosterone(T) to epitestosertone(E) in the urine of a competitor constitutes an offense unless there is evidence that this ratio is due to a physiological or pathological, e.g. low epitestosterone excretion, androgen production of tumor or enzyme deficiencies.” It is generally accepted that raising natural or unnatural testosterone levels before, during or after concentric weight training may contribute to rapid muscle fiber growth and strength gains(Celotti & Negri Cesi 1992) in order to meet imposed resistance demands, but the application to endurance sports is seriously questioned by the sport scientists which contribute to both ACSM and USOC organization policies.

Infact the above-referred scientific finding has given birth to alternate source of DHEA.

Under which act the usage of Natural & synthetic DHEA has become popular in USA.

Dietary Supplemental Health and Education Act of 1994

The Dietary Supplemental Health and Education Act of 1994 (DSHEA) is an act that removes the regulation of dietary supplements from the Federal Food, Drug and Cosmetic Act (FD&C). Under the FD&C, the DSA evaluated the safety of all new ingredients, including those used in dietary supplements. Congress ammended the FD&C Act in 1994 with the DSHEA which includes provisions that apply only to dietary supplements and dietary ingredients of dietary supplements. It should be kept in mind that dietary supplement need not be only a pharmaceutical; it can be a food or beverage. Therefore an understanding of the DSHEA is important to developers of these types of products. The major result of the DSHEA Act of 1994 is that dietary ingredients used in dietary supplements are no longer subject to the premarket safety evaluations required of other new food ingredients or for new uses of old food ingredients.

Definition of Dietary Supplement (as dictated by the U.S. Food and Drug Administration)

The DSHEA expands the definition beyond essential nutrients to also include things such as ginseng, garlic, fish oils, psyllium, enzymes, glandulars, and mixtures of things. More formally, the DSHEA has several criteria for dietary supplement. A product that is intended to supplement the diet that bears or contains one or more of the following dietary ingredients: a vitamin, a mineral, an herb or other botanical, an amino acid, a dietary substance for use by man to supplement the diet by increasing the total daily intake, or the concentrate, metabolite, constituent, extract, or combination of these ingredients, intended for ingestion in pill, capsule, tablet or liquid form.

Nutritional Label Claims

Nutritional support statements are important to food, beverage and nutraceutical manufacturers who want to make some label claim. The DSHEA does provide for the use of various types of statements as long as none of them make any claims to diagnose, prevent, mitigate, treat, or cure a specific disease (unless approved under the new drug provisions of the FD&C Act). Claims authorized by the FDA are of course allowed. An example here is that calcium may reduce the risk of osteoporosis. Statements about classical nutrient deficiency diseases can be made as long as the statement discloses the prevalence of the disease in the United States. The most important to our industry is the ability to describe the supplement’s effect on “structure or function” of the body or the “well-being” achieved by consuming the dietary supplement.